Metabolism & Weight

Sourced guides to midlife weight, belly fat, insulin resistance, prediabetes and GLP-1 medicines, and what the evidence says actually helps.

Weight and energy often change in midlife, even when your habits have not. Hormonal shifts, insulin resistance, stress and sleep all play a part.

These guides explain hormonal weight gain, belly fat and cortisol, insulin resistance and blood sugar, and newer medicines such as GLP-1s, with the tests to ask for and the changes that have real evidence behind them.

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Belly Fat & Cortisol

Stubborn belly fat in midlife is linked to falling estrogen and insulin resistance, and — to a smaller degree than marketing suggests — to cortisol.

GLP-1 for Weight Loss

GLP-1 medicines such as semaglutide and tirzepatide: how they fit into midlife health, common and serious side effects, contraception and pregnancy, and what happens when you stop.

Hormonal Weight Gain

Why weight can change in midlife, from hormones to sleep, muscle loss and stress, and what the evidence says actually helps.

All Metabolism & Weight guides